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Chemosaturation
Chemosaturation therapy has been shown to help slow or reverse the progression of tumours from certain cancers in the liver. At our specialist centre in Southampton, UK we offer treatment for liver metastases arising from ocular melanoma.
News
Our paper shows excellent response rates in uveal melanoma patients with liver metastases. There was significantly improved survival and safety compared to previous studies and a trend towards a reduction in complications with excellent patient experience over time.
Chemosaturation with percutaneous hepatic perfusion of melphalan for metastatic uveal melanoma
What is Chemosaturation?
The concept involves temporarily isolating the liver from the body’s blood circulation and delivering a highly concentrated dose of an anti-cancer drug (melphalan) directly to the liver, thereby ‘saturating’ the entire organ. Blood leaving the liver is directed to filters outside of the body in order to remove most of the anti-cancer drug before it is returned to the body.
Because the liver is isolated, a much higher concentration of the anti-cancer drug can be administered than in systemic chemotherapy. By delivering this drug to the entire liver, we are able to potentially treat undetected micro-tumours as well as visible tumours.